Medicine

Accelerating ASO treatments from development to application

.Competing interests.R.S., M.S., H.G. as well as A.A.R. are actually coordinators of the 1M1M initiative. H.G. and A.A.R. are actually board of supervisors participants as well as R.S., M.S. and also A.A.R. are actually participants of the scientific consultatory committee of N1C. A.A.R. reveals work by LUMC, which has patents on exon-skipping technology, a number of which has actually been actually licensed to BioMarin and also ultimately sublicensed to Sarepta. As co-inventor of several of these licenses, A.A.R. was actually qualified to a share of royalties. A.A.R. better discloses functioning as ad hoc expert for PTC Rehabs, Sarepta Rehabs, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco as well as Astra Zeneca. Over the last 5 years, A.A.R. also executed speaking to for Alpha Anomeric. A.A.R. additionally states registration of the scientific advisory boards of Eisai, Hybridize Therapeutics, Muteness Therapeutics, Sarepta Therapies, Sapreme and Mitorx. Previously 5 years, A.A.R. was actually likewise a scientific board of advisers participant for ProQR. Commission for A.A.R. u00e2 s consulting and also advising tasks is paid to LUMC. Previously 5 years, LUMC additionally acquired speaker gratuity coming from PTC Rehabs, Alnylam Netherlands, Italfarmaco and also Pfizer and financing for contract investigation coming from Sapreme, Eisai, Galapagos, Synaffix and also Alpha Anomeric. Task funding is obtained from Sarepta Rehabs and Entrada using unregulated gives. H.G. possesses nothing to disclose in relation to the subject matters dealt with in this document. In the past 5 years, he has actually likewise obtained working as a consultant honoraria from UCB. M.S. acquired consultancy gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly as well as Solaxa in the past 5 years, all unassociated to the present document. R.S. possesses nothing to divulge in connection with the topics covered within this composition. She has actually acquired speaker and/or consultancy honoraria or funding contributions from Abbvie, Bial, STADA and Everpharma previously 5 years.